Rudd Lab

dNTP metabolism • Genome stability

Cancer biology & therapeutics

The Rudd lab investigates metabolic pathways operating inside cancer cells and how these pathways support malignant disease. We are particularly focused upon the metabolic interplay between the DNA precursor pool and the DNA molecule, a relationship that is fundamental to cancer biology, underpinning key aspects of oncogenesis together with therapy resistance. We apply a multidisciplinary approach centred upon gaining a detailed mechanistic understanding of these pathways, allowing the identification of potential biomarkers and therapeutic targets that can be exploited to rationally improve the treatment of cancer.

News

May, 2022

Our new review article on targeting nucleotide metabolism in cancer is now published

April, 2022

We're very happy to receive funding from the Dr Åke Olsson Foundation for Hematological Research

March, 2022

Congratulations to Miriam who has been awarded a postdoctoral fellowship from Barncancerfonden (Swedish Childhood Cancer Fund)

February, 2022

We're very happy our proposal for a Chemical Biology & Genome Engineering Platform Pilot Project has been selected for funding

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We are recruiting a PhD student! Get in touch if you're interested and check out the application for more details

November, 2021

We welcome Femke - new postdoc - to the group!

October, 2021

We're very happy to receive KID-funding from Karolinska Institutet, which will allow us to recruit a PhD student to the team!

April, 2021

Our new method paper on probing small molecule interaction with the dNTPase SAMHD1 is now published

March, 2021

We are recruiting a postdoc! Get in touch if you're interested and check out the application for more details

January, 2021

Our paper on drug synergy scoring of cancer therapeutics is now published

November, 2020

We're very happy and grateful to receive project funding from the Swedish Cancer Society (Cancerfonden)

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Our new preprint on drug synergy scoring of cancer therapuetics is up on bioRxiv

See also tweet thread summarising the story from Sean

October, 2020

We welcome Miriam - new postdoc - to the group!

July, 2020

Our new preprint on SAMHD1 and oncogene-induced replication stress is up on bioRxiv

April, 2020

We are recruiting a postdoc! Get in touch if you're interested

January, 2020

Our paper targeting the chemoresistance factor SAMHD1 with existing anticancer drugs is now published

See press release from Karolinska Instituet and tweet thread summarising the story from Sean