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Methods
SAMHD1 activity assay
A versatile enzyme-coupled SAMHD1 activity assay, deployed in a 384-well microplate format, that allows for the evaluation of small molecules and nucleotide analogues as SAMHD1 substrates, activators, and inhibitors.
Publication: A High-Throughput Enzyme-Coupled Activity Assay to Probe Small Molecule Interaction with the dNTPase SAMHD1 (2021)
Datasets
SAMHD1 inhibitor screen dataset
A diverse small molecule library was tested for inhibition of recombinant SAMHD1 using an enzyme-coupled malachite green assay by measuring absorbance at 630 nm.
Dataset: https://www.ebi.ac.uk/chembl/explore/document/CHEMBL5483193
Publication: Identification and evaluation of small-molecule inhibitors against the dNTPase SAMHD1 via a comprehensive screening funnel (2024)
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